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Circadian disruption in beta-Bmal1(-/-) mice and arrhythmic Clock 19 mice decrease the Nrf2 expression and subsequently impair the antioxidant defense system, contributing to increased ROS accumulation, oxidative damage and mitochondrial uncoupling

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TNF- downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA A receptors

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Popichak KA, Hammond SL, Moreno JA et al (2018) Compensatory expression of Nur77 and Nurr1 regulates NF-B-dependent inflammatory signaling in astrocytes

Research in animal models indicates that AHK-Cu is an effective stimulator of collagen synthesis